First Ever High-Intensity Focused Ultrasound (HIFU) Surgery Performed on Pediatric Patient at Children’s National

&#13
&#13
&#13
&#13
&#13
&#13
&#13
February 09, 2022&#13
&#13

&#13
&#13
Researchers watch their monitors as a patient undergoes an exam.&#13
&#13
&#13
&#13
Impression supplied by Insightec&#13
&#13
&#13

Children’s Nationwide Clinic productively executed the to start with-ever higher-intensity centered ultrasound (HIFU) surgical treatment on a pediatric client with neurofibromatosis (NF). This is the youngest affected individual to undertake HIFU therapy in the world. The improvement of children’s clinical devices in the U.S. carries on to significantly lag behind grownup gadgets. This is why this milestone marks a substantial progress in generating pediatric surgical treatment a lot more exact and a lot less invasive.

The medical center is offering this remedy to individuals below an ongoing investigation clinical demo. Children’s Countrywide is one of the first pediatric hospitals in the country to use HIFU for neuro-oncology individuals. It is also the initially hospital in the world to use it to take care of a pediatric individual with NF. NF is a affliction that takes place in somewhere around 1 in 3,500 births and brings about tumors to kind in the brain, spinal wire and nerves.

“Using HIFU to address our pediatric individuals is a quantum leap toward non-invasive surgical treatment for young ones,” explained Robert Keating, M.D., division chief of Neurosurgery and co-director of the HIFU application at Children’s Countrywide. “It’s fascinating due to the fact the long run is now listed here and it’s drastically much better for our young ones, in terms of non-invasive surgery with decreased possibility of issues and no publicity to radiation.”

Targeted ultrasound (FUS) is a non-invasive therapeutic technological innovation with the opportunity to renovate the cure of a lot of healthcare disorders by utilizing ultrasonic thermal power to especially focus on tissue deep in the entire body. The technological innovation can handle with no incisions or the require of radiation.

FUS, which has been made use of for grownup medical trials for numerous decades, can be sent by means of superior- or lower-depth concentrated ultrasound (LIFU). HIFU uses non-invasive remedy that uses concentrated ultrasound waves to thermally ablate a focal spot of tissue. Children’s Countrywide will now use HIFU to address minimal-grade style tumors positioned in difficult spots of the mind, these as hypothalamic hamartomas and pilocytic astrocytoma, as nicely as for movement disorders and epilepsy.

An alternate strategy, LIFU uses reduced amounts of power to disrupt the blood-brain barrier. Compared with prescription drugs, which usually have problems crossing the blood-brain barrier, LIFU can transiently open up the blood-brain barrier to chemotherapy. This may well enable much more efficient treatment of tumors and provide chances to handle, for the first time, the total extent of a malignant brain tumor.

“Having concentrated ultrasound know-how as a instrument and conducting medical trials will make it possible for our neurologists and oncologists to supply a non-invasive treatment possibility to quite a few sufferers who put up with from neurological situations,” said Hasan Syed, M.D., co-director of the HIFU center at Children’s Countrywide. “The milestone of performing this to start with HIFU treatment will direct the way to much better knowledge of the result of this engineering and supply people with additional selections.”

At Children’s Nationwide, the HIFU plan is being led by Dr. Keating and a multidisciplinary staff, like clinicians and investigators from the Sheik Zayed Institute for Pediatric Innovation, radiology, oncology, surgery and orthopedics. In an work to collaborate with the region’s grownup hospitals, Children’s Countrywide will also deal with adult clients on a selective basis who have movement ailments this kind of as crucial tremor and Parkinson’s. There is a shortage of comparable methods in the metro area. Quite a few grownup individuals deal with 1-year wait periods for treatment of their motion diseases, demanding a lot of to travel out of state for treatment.

The LIFU application is scheduled to be operational in 2022. It will most likely be the to start with in the U.S. to take care of superior-grade pediatric brain tumors with disruption of the blood-brain barrier and supply more powerful routes for chemotherapy as well as potential immunotherapy and molecular methods.

“The use of LIFU with microbubbles to open up the blood-brain barrier is an interesting, probably sport-modifying strategy for young children with these tumors,” said Roger Packer, M.D., senior vice president of the Center for Neuroscience and Behavioral Medicine at Children’s Nationwide. “It really should safely allow the blood-mind barrier to open and permit delivery of potentially existence-preserving personalised remedy to the tumor and spare the relaxation of the brain. It is the most fascinating, new advancement in brain tumor remedy for these malignant midline tumors in the past 50 yrs.”

Children’s Countrywide proceeds to be a chief in pediatric HIFU use. In 2015, Children’s Nationwide physicians became the very first in the U.S. to use MR-HIFU to handle pediatric osteoid osteoma – a benign, but unpleasant bone tumor. Thriving medical demo effects led to FDA approval in early 2021 for the use of the engineering for this cure. In 2020, the Focused Ultrasound Foundation also designated Children’s Countrywide as the to start with world pediatric Center of Excellence for employing this technologies to assist sufferers with specific types of childhood tumors.

Video clip: You can access interviews here and b-roll of the HIFU technology here.

Media contact: Ariana Perez | 202-476-4500


About Children’s National Medical center

Children’s Nationwide Healthcare facility, dependent in Washington, D.C., was recognized in 1870 to assist every youngster increase up stronger. Today, it is among the the nation’s top rated 10 children’s hospitals. It is rated No. 1 for newborn care for the fifth straight calendar year and ranked in all specialties evaluated by U.S. News & Globe Report. Children’s Nationwide is reworking pediatric medicine for all youngsters. The Children’s National Exploration & Innovation Campus opened in 2021, a very first-of-its-kind pediatric hub devoted to developing new and far better techniques to care for little ones. Children’s National has been designated three moments in a row as a Magnet® clinic, demonstrating the greatest benchmarks of nursing and affected individual care shipping and delivery. This pediatric academic health system delivers qualified treatment by way of a easy, group-primarily based primary care network and specialty care locations in the D.C. metropolitan location, which include Maryland and Virginia. Children’s Nationwide is house to the Children’s National Investigation Institute and Sheikh Zayed Institute for Pediatric Surgical Innovation. It is acknowledged for its know-how and innovation in pediatric care and as a robust voice for kids through advocacy at the neighborhood, regional and national amounts.

For a lot more details, follow us on Facebook, Instagram, Twitter and LinkedIn.

Previous post What It Could Mean If You’re Letting Friendships Slip Away During COVID
Next post On-Site Pharmacy Gives Kids and Families Access to Groceries